Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen.

Abstract

This study was aimed to analyse and compare the bioenergetics and oxidative status of mitochondria isolated from liver, heart and brain of ovariectomized rat females treated with 17β-estradiol (E2) and/or tamoxifen (TAM). E2 and/or TAM did not alter significantly the respiratory chain of the three types of mitochondria. However, TAM significantly decreased… (More)
DOI: 10.1016/j.jsbmb.2010.09.004

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