Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus.

@article{GonzalezDosal2012MitochondriaderivedRO,
  title={Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus.},
  author={Regina Gonzalez-Dosal and Kristy A. Horan and S\oren R Paludan},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={418 4},
  pages={806-10}
}
Reactive oxygen species (ROS) are crucial secondary messengers of signaling pathways. Redox-dependent signaling events have been previously described in the innate immune response. However, the mechanism by which ROS modulates anti-viral innate immune signaling is not fully clarified. Here, we report that mitochondria-derived ROS differentially regulate the innate response to DNA and RNA viruses (herpes simplex virus (HSV) and Sendai virus (SeV), respectively), with the cytokine response to HSV… CONTINUE READING

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