Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani.

@article{Roy2008MitochondriadependentRO,
  title={Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani.},
  author={Amit Roy and Agneyo Ganguly and Somdeb Bosedasgupta and Benu Brata Das and Churala Pal and Parasuraman Jaisankar and Hemanta Kumar Majumder},
  journal={Molecular pharmacology},
  year={2008},
  volume={74 5},
  pages={1292-307}
}
Mitochondria are the principal site for the generation of cellular ATP by oxidative phosphorylation. F0F1-ATP synthase, a complex V of the electron transport chain, is an important constituent of mitochondria-dependent signaling pathways involved in apoptosis. In the present study, we have shown for the first time that 3,3'-diindolylmethane (DIM), a DNA topoisomerase I poison, inhibits mitochondrial F0F1-ATP synthase of Leishmania donovani and induces programmed cell death (PCD), which is a… CONTINUE READING