Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.

@article{Issop2015MitochondriaassociatedMF,
  title={Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.},
  author={Leeyah Issop and Jinjiang Fan and Sunghoon Lee and Malena B. Rone and Kaustuv Basu and Jeannie Mui and Vassilios Papadopoulos},
  journal={Endocrinology},
  year={2015},
  volume={156 1},
  pages={334-45}
}
Leydig cell steroidogenesis is a multistep process that takes place in the mitochondria and endoplasmic reticulum (ER). The physical association between these 2 organelles could facilitate both steroidogenesis substrate availability and mitochondrial product passage to steroidogenic enzymes in the ER, thus regulating the rate of steroid formation. Confocal microscopy, using antisera against organelle-specific antigens, and electron microscopy studies demonstrated that there is an increase in… CONTINUE READING

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