Mitochondria as subcellular targets for clinically useful anthracyclines.

  title={Mitochondria as subcellular targets for clinically useful anthracyclines.},
  author={Kirsten Jung and Regina Reszka},
  journal={Advanced drug delivery reviews},
  volume={49 1-2},
Due to the widespread use of anthracyclines as antitumor agents, a large number of investigations have been reported analyzing clinical and molecular aspects of these quinone antibiotics. While the high affinity of anthracyclines towards chromosomal DNA has been held responsible for their antitumor activity, an increasing amount of data is being accumulated showing that these drugs also target mitochondria thus interfering with major mitochondrial functions. Since this toxicity of… CONTINUE READING
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