Mitochondria as signaling organelles in the vascular endothelium.

@article{Quintero2006MitochondriaAS,
  title={Mitochondria as signaling organelles in the vascular endothelium.},
  author={Margarito Quintero and Sergio L. Colombo and Andrew Aydon Godfrey and Salvador Moncada},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 14},
  pages={
          5379-84
        }
}
Vascular endothelial cells are highly glycolytic and consume relatively low amounts of oxygen (O(2)) compared with other cells. We have confirmed that oxidative phosphorylation is not the main source of ATP generation in these cells. We also show that at a low O(2) concentration (<1%) endogenous NO plays a key role in preventing the accumulation of the alpha-subunit of hypoxia-inducible factor 1. At higher O(2) concentrations (1-3%) NO facilitates the production of mitochondrial reactive oxygen… CONTINUE READING

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