Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells.

@article{Belyaeva2008MitochondriaAA,
  title={Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells.},
  author={Elena A. Belyaeva and Dorota Dymkowska and Mariusz Roman Wieckowski and Lech Wojtczak},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={231 1},
  pages={34-42}
}
The mechanisms of toxic effects of divalent cations of three heavy metals Hg, Cd and Cu in rat ascites hepatoma AS-30D cells cultivated in vitro were compared. It was found that the toxicity of these ions, applied in the micromolar range (10-500 microM), decreased from Hg(2+) (most toxic) to Cu(2+) (least toxic). Hg(2+) and Cd(2+) produced a high percentage… CONTINUE READING