Mitochondria as a therapeutic target for aging and neurodegenerative diseases.

Abstract

Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence from animal models, postmortem brain studies of and clinical studies of aging and neurodegenerative diseases suggests that mitochondrial function is defective in aging and neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Several lines of research suggest that mitochondrial abnormalities, including defects in oxidative phosphorylation, increased accumulation of mitochondrial DNA defects, impaired calcium influx, accumulation of mutant proteins in mitochondria, and mitochondrial membrane potential dissipation are important cellular changes in both early and late-onset neurodegenerative diseases. Further, emerging evidence suggests that structural changes in mitochondria, including increased mitochondrial fragmentation and decreased mitochondrial fusion, are critical factors associated with mitochondrial dysfunction and cell death in aging and neurodegenerative diseases. This paper discusses research that elucidates features of mitochondria that are associated with cellular dysfunction in aging and neurodegenerative diseases and discusses mitochondrial structural and functional changes, and abnormal mitochondrial dynamics in neurodegenerative diseases. It also outlines mitochondria-targeted therapeutics in neurodegenerative diseases.

02004002011201220132014201520162017
Citations per Year

989 Citations

Semantic Scholar estimates that this publication has 989 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Reddy2011MitochondriaAA, title={Mitochondria as a therapeutic target for aging and neurodegenerative diseases.}, author={P. Hemachandra Reddy and Tiyyagura Koti Reddy}, journal={Current Alzheimer research}, year={2011}, volume={8 4}, pages={393-409} }