Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease.

@article{Aliev2004MitochondriaAA,
  title={Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease.},
  author={Gjumrakch Aliev and Mark A. Smith and Jack C. de la Torre and George Perry},
  journal={Mitochondrion},
  year={2004},
  volume={4 5-6},
  pages={649-63}
}
It has been widely accepted that vascular hypoperfusion induces oxidative stress and the outcome of this misbalance is brain energy failure. This abnormality leads to neuronal death which manifests as cognitive impairment and the development of brain pathology as in Alzheimer's disease (AD). It has been demonstrated that the AD brain is characterized by impairments in energy metabolism. We theorize that hypoperfusion induced mitochondrial failure plays a key role in the generation of reactive… CONTINUE READING
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