Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling.

  title={Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling.},
  author={Li Hong Bao and Marat V. Avshalumov and Jyoti C Patel and Christian Ryan Lee and Evan W Miller and Christopher J Chang and Margaret E Rice},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 28},
Hydrogen peroxide (H(2)O(2)) is emerging as a ubiquitous small-molecule messenger in biology, particularly in the brain, but underlying mechanisms of peroxide signaling remain an open frontier for study. For example, dynamic dopamine transmission in dorsolateral striatum is regulated on a subsecond timescale by glutamate via H(2)O(2) signaling, which activates ATP-sensitive potassium (K(ATP)) channels to inhibit dopamine release. However, the origin of this modulatory H(2)O(2) has been elusive… CONTINUE READING


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