Mitochondria are a major site for folate and thymidylate synthesis in plants.

@article{Neuburger1996MitochondriaAA,
  title={Mitochondria are a major site for folate and thymidylate synthesis in plants.},
  author={Michel Neuburger and Fabrice R{\'e}beill{\'e} and Agn{\`e}s Jourdain and Satsuki Nakamura and Roland Douce},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 16},
  pages={9466-72}
}
The subcellular distributions of folate and folate-synthesizing enzymes were investigated in pea leaves. It was observed that the mitochondrial folate pool (approximately 400 micron) represented approximately 50% of the total pool. Furthermore, all the enzymes involved in tetrahydrofolate polyglutamate synthesis were present in the mitochondria. In marked contrast, we failed to detect any significant activity of these enzymes in chloroplasts, cytosol, and nuclei. The presence of the… CONTINUE READING

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