Mitochondria and the heart.

@article{Hirano2001MitochondriaAT,
  title={Mitochondria and the heart.},
  author={M Hirano and Michael Davidson and Salvatore Dimauro},
  journal={Current opinion in cardiology},
  year={2001},
  volume={16 3},
  pages={
          201-10
        }
}
Since the identification of the first pathogenic mutations of mitochondrial DNA in 1988, a plethora of information about human mitochondrial diseases has been brought to light. Not surprisingly, many of these disorders affect the myocardium, because this tissue relies heavily upon oxidative metabolism. This review focuses on disorders of the respiratory chain, the only area of mammalian cellular metabolism under the control of two genomes, nuclear and mitochondrial. Consequently, defects of… CONTINUE READING
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