Mitochondria and the autophagy-inflammation-cell death axis in organismal aging.

  title={Mitochondria and the autophagy-inflammation-cell death axis in organismal aging.},
  author={Douglas R Green and Lorenzo Galluzzi and Guido Kroemer},
  volume={333 6046},
Alterations of mitochondrial functions are linked to multiple degenerative or acute diseases. As mitochondria age in our cells, they become progressively inefficient and potentially toxic, and acute damage can trigger the permeabilization of mitochondrial membranes to initiate apoptosis or necrosis. Moreover, mitochondria have an important role in pro-inflammatory signaling. Autophagic turnover of cellular constituents, be it general or specific for mitochondria (mitophagy), eliminates… CONTINUE READING
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Complementary and Alternative Medicine for Older Adults: A Guide to Holistic Approaches to Healthy Aging (Springer

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