Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications.

@article{Bolaos2009MitochondriaAR,
  title={Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications.},
  author={Juan P Bola{\~n}os and Mar{\'i}a {\'A}ngeles Moro and Ignacio Lizasoain and Angeles Almeida},
  journal={Advanced drug delivery reviews},
  year={2009},
  volume={61 14},
  pages={1299-315}
}
Mitochondria represent both the main source and target of reactive oxygen and nitrogen species (RONS). In view of the large energy expenditure made by neurons during neurotransmission, an intact mitochondrial function is of paramount importance for the correct function of the brain. Accordingly, the search of therapeutic strategies against situations in which there is an abnormal brain function, such as neurological disorders and stroke, should be focused towards mitochondria. Here, we have… CONTINUE READING

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