Mitochondria and neuronal survival.

@article{Nicholls2000MitochondriaAN,
  title={Mitochondria and neuronal survival.},
  author={David G. Nicholls and Samantha L. Budd},
  journal={Physiological reviews},
  year={2000},
  volume={80 1},
  pages={
          315-60
        }
}
Mitochondria play a central role in the survival and death of neurons. The detailed bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca(2+), generate reactive oxygen species, and undergo Ca(2+)-dependent permeabilization of their inner membrane are currently being applied to the function of mitochondria in situ within neurons under physiological and pathophysiological conditions. Here we review the functional bioenergetics of isolated mitochondria, with emphasis on… 
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