Mitochondria and metazoan epigenesis.

  title={Mitochondria and metazoan epigenesis.},
  author={James A. Coffman},
  journal={Seminars in cell & developmental biology},
  volume={20 3},
In eukaryotes, mitochondrial activity controls ATP production, calcium dynamics, and redox state, thereby establishing physiological parameters governing the transduction of biochemical signals that regulate nuclear gene expression. However, these activities are commonly assumed to fulfill a 'housekeeping' function: necessary for life, but an epiphenomenon devoid of causal agency in the developmental flow of genetic information. Moreover, it is difficult to perturb mitochondrial function… CONTINUE READING