Mitochondria and ischemic reperfusion damage in the adult and in the developing brain.

@article{Blomgren2003MitochondriaAI,
  title={Mitochondria and ischemic reperfusion damage in the adult and in the developing brain.},
  author={Klas Blomgren and Changlian Zhu and Ulrika Hallin and Henrik H Hagberg},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={304 3},
  pages={551-9}
}
The developing and the adult brain respond in similar ways to ischemia, but also display clear differences. For example, the relative contributions of necrosis and apoptosis to neuronal death may be different, such that apoptotic mechanisms would be more prevalent in the developing brain. During normal development, more than half of the neurons in some brain regions are removed through apoptosis, and effectors like caspase-3 are highly upregulated in the immature brain. Mitochondria are pivotal… CONTINUE READING