Mitochondria and immunity in chronic fatigue syndrome

@article{Anderson2020MitochondriaAI,
  title={Mitochondria and immunity in chronic fatigue syndrome},
  author={George Anderson and Michael Maes},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2020},
  volume={103}
}
  • G. Anderson, M. Maes
  • Published 26 May 2020
  • Biology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
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It is suspected that the microbiome may contribute to neurocognitive impairments of ME/CFS patients and the therapeutic potential of fecal microbiota transfer and of targeted dietary interventions should be systematically evaluated.
Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
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An overview of the pathophysiological mechanisms during heat stroke and similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome are described, which suggest common pathways in the physiological responses to very different forms of stressors, which are manifested in different clinical outcomes.
Animal Models for Neuroinflammation and Potential Treatment Methods
TLDR
The findings of the included studies suggest that anti-inflammatory substances may be used as effective therapies to ameliorate disease symptoms in patients with ME/CFS.
Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
TLDR
This paper summarizes and expands on the previous publications about the relevance of findings from critical illness for ME/CFS and describes interlinkages between these pathophysiological mechanisms as well as “vicious cycles” involving cytokines and inflammation that may contribute to explain the chronic nature of these illnesses.
In schizophrenia, chronic fatigue syndrome- and fibromyalgia-like symptoms are driven by breakdown of the paracellular pathway with increased zonulin and immune activation-associated neurotoxicity.
TLDR
FF symptoms are part of the phenome of schizophrenia and BCPS-worsening as well, and belong to a common core shared by G-CoDe, symtopmatome, and QoL phenomenome.
COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review
TLDR
There is currently insufficient evidence to establish COVID-19 as an infectious trigger for ME/CFS, but there are important similarities between post-acute CO VID-19 symptoms and ME/ CFS.
SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing
TLDR
The data that might support the idea that mitochondrial health, induced by a healthy lifestyle, could be a key factor in resisting the virus, and for those people who are perhaps not in optimal health, treatments that could support mitochondrial function might be pivotal to their long-term recovery are reviewed.
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
TLDR
Overall, the findings support the use of CoQ10 plus NADH supplementation as a potentially safe therapeutic option for reducing perceived cognitive fatigue and improving the health-related quality of life in ME/CFS patients.
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