Mitochondria and human cancer.

  title={Mitochondria and human cancer.},
  author={Josephine S. Modica-Napolitano and Mariola Kulawiec and Keshav K. Singh},
  journal={Current molecular medicine},
  volume={7 1},
The better part of a century has passed since Otto Warburg first hypothesized that unique phenotypic characteristics of tumor cells might be associated with an impairment in the respiratory capacity of these cells. Since then a number of distinct differences between the mitochondria of normal cells and cancer cells have been observed at the genetic, molecular, and biochemical levels. This article begins with a general overview of mitochondrial structure and function, and then outlines more… CONTINUE READING

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