Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

@article{Tan2013MitochondriaAC,
  title={Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes},
  author={Dun‐xian Tan and Lucien C. Manchester and Xiaoyan Liu and Sergio A. Rosales-Corral and Dar{\'i}o Acu{\~n}a-Castroviejo and Russel Joseph Reiter},
  journal={Journal of Pineal Research},
  year={2013},
  volume={54}
}
Mitochondria and chloroplasts are major sources of free radical generation in living organisms. Because of this, these organelles require strong protection from free radicals and associated oxidative stress. Melatonin is a potent free radical scavenger and antioxidant. It meets the criteria as a mitochondrial and chloroplast antioxidant. Evidence has emerged to show that both mitochondria and chloroplasts may have the capacity to synthesize and metabolize melatonin. The activity of… Expand
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