Mitochondria and cellular oxygen sensing in the HIF pathway.

  title={Mitochondria and cellular oxygen sensing in the HIF pathway.},
  author={Cormac T Taylor},
  journal={The Biochemical journal},
  volume={409 1},
Mitochondrial respiration is responsible for more than 90% of oxygen consumption in humans. Cells utilize oxygen as the final electron acceptor in the aerobic metabolism of glucose to generate ATP which fuels most active cellular processes. Consequently, a drop in tissue oxygen levels to the point where oxygen demand exceeds supply (termed hypoxia) leads rapidly to metabolic crisis and represents a severe threat to ongoing physiological function and ultimately, viability. Because of the central… CONTINUE READING
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