Mitochondria and ageing.

  title={Mitochondria and ageing.},
  author={David A. Cottrell and Douglass Matthew Turnbull},
  journal={Current opinion in clinical nutrition and metabolic care},
  volume={3 6},
Mitochondria have long been proposed as a perpetrator of aging. We review here the accumulating evidence for chronological alterations in the mitochondrion and discuss how these changes may cause cellular dysfunction and death. We conclude that although the evidence for aging changes in the level of oxidative stress, DNA mutations and biochemical deficiencies in mitochondria are convincing, there is little experimental evidence to link these changes directly with the cellular pathology of aging… CONTINUE READING