Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis.

  title={Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosis.},
  author={Shaoning Jiang and Dae Won Park and William S Stigler and Judy R. Creighton and Saranya Ravi and Victor M. Darley-Usmar and Jaroslaw W Zmijewski},
  journal={The Journal of biological chemistry},
  volume={288 36},
Defective clearance of apoptotic cells is frequently associated with perpetuation of inflammatory conditions. Our results show a rapid activation of AMP-activated kinase (AMPK) in macrophages upon exposure to apoptotic cells or lysophosphatidylcholine, a specific phospholipid that is produced and released from dying cells. AMPK activation resulted from inhibition of mitochondrial oxygen consumption and ATP production and further depended on Ca(2+) mobilization and mitochondrial reactive oxygen… CONTINUE READING


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