Mitochondria-Targeted and Ultrasound-Activated Nanodroplets for Enhanced Deep-Penetration Sonodynamic Cancer Therapy.

@article{Zhang2019MitochondriaTargetedAU,
  title={Mitochondria-Targeted and Ultrasound-Activated Nanodroplets for Enhanced Deep-Penetration Sonodynamic Cancer Therapy.},
  author={Liang Zhang and Hengjing Yi and Jiao Jiao Song and Ju Wen Huang and Ke Yang and Bin Tan and Dong Wang and Nanlan Yang and Zhigang Wang and Xingsheng Li},
  journal={ACS applied materials & interfaces},
  year={2019},
  volume={11 9},
  pages={
          9355-9366
        }
}
Sonodynamic therapy (SDT), a promising alternative for cancer therapy, utilizes a sonosensitizer combined with ultrasound (US) irradiation to damage tumor cells/tissues for therapeutic purposes. The ability of sonosensitizers to specifically accumulate in tumor cells/tissues could greatly influence their therapeutic efficiency. In this work, we report the use of US-activated sonosensitizer (IR780)-based nanodroplets (IR780-NDs) for SDT, which provide numerous benefits for killing cancer cells… CONTINUE READING
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