Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

@inproceedings{Cha2012MitochondriaSpecificAO,
  title={Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death},
  author={Moon-Yong Cha and Sun-ho Han and Sung Min Son and H Hong and Young-Ju Choi and Jayoung Byun and Inhee Mook-jung},
  booktitle={PloS one},
  year={2012}
}
Mitochondria are best known as the essential intracellular organelles that host the homeostasis required for cellular survival, but they also have relevance in diverse disease-related conditions, including Alzheimer's disease (AD). Amyloid β (Aβ) peptide is the key molecule in AD pathogenesis, and has been highlighted in the implication of mitochondrial abnormality during the disease progress. Neuronal exposure to Aβ impairs mitochondrial dynamics and function. Furthermore, mitochondrial A… CONTINUE READING
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