Mitochondria Influence Fas Expression in GP120-Induced Apoptosis of Neuronal Cells

@article{Thomas2009MitochondriaIF,
  title={Mitochondria Influence Fas Expression in GP120-Induced Apoptosis of Neuronal Cells},
  author={Sunil Thomas and Lloyd F. Mayer and Kirk E Sperber},
  journal={International Journal of Neuroscience},
  year={2009},
  volume={119},
  pages={157 - 165}
}
The human immunodeficiency virus-1 (HIV-1) destroys the immune system and also induces neurological disease culminating into dementia (HIV-associated dementia). Though the HIV viral protein gp120 induces apoptosis in neuronal cells, the mechanism of action is still poorly defined. Recent studies show that cells die during apoptosis by Fas aggregation aided by the mitochondrial proapoptotic proteins. Our studies show an increase in expression of Fas and its associated downstream proteins after… Expand
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