Mitochondria – the kraken wakes!

@article{Miller1998MitochondriaT,
  title={Mitochondria – the kraken wakes!},
  author={Richard J. Miller},
  journal={Trends in Neurosciences},
  year={1998},
  volume={21},
  pages={95-97}
}
One of the major ways in which mitochondria appear to be able to participate in cellular pathology is through activation of the MPT. As discussed earlier, when the channel opens transiently it can mediate normal signaling events. However, opening of the MPT in the high-conductance mode appears to be irreversible and has some profound consequences for cell function. For example, MPT activation of this type is associated with osmotic changes and mitochondrial swelling. The mitochondrial cristae… Expand
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