Mitochondria – the kraken wakes!

@article{Miller1998MitochondriaT,
  title={Mitochondria – the kraken wakes!},
  author={Richard J. Miller},
  journal={Trends in Neurosciences},
  year={1998},
  volume={21},
  pages={95-97}
}
One of the major ways in which mitochondria appear to be able to participate in cellular pathology is through activation of the MPT. As discussed earlier, when the channel opens transiently it can mediate normal signaling events. However, opening of the MPT in the high-conductance mode appears to be irreversible and has some profound consequences for cell function. For example, MPT activation of this type is associated with osmotic changes and mitochondrial swelling. The mitochondrial cristae… Expand
View on Elsevier
doi.org
44 Citations
Background Citations
19

44 Citations

Citation Type

Citation Type

Evolutionary and Functional Mitogenomics Associated With the Genetic Restoration of the Florida Panther
3. The Living Cell
Intracellular zinc is a critical intermediate in the excitotoxic cascade
Phenotypic characterization of PNPase knockdown in C. elegans
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?
Exposure of cyclosporin A in whole blood, cerebral spinal fluid, and brain extracellular fluid dialysate in adults with traumatic brain injury.
Induction of the mitochondrial permeability transition (MPT) by micromolar iron: liberation of calcium is more important than NAD(P)H oxidation.
Glucose and its metabolites have distinct effects on the calcium-induced mitochondrial permeability transition.
The nitric oxide signaling pathway inhibits intracellular calcium release to prevent neurodevelopmental alcohol toxicity
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Bright and dark sides of nitric oxide in ischemic brain injury
Double identity for proteins of the Bcl-2 family
Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases
Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals
Mitochondrial Implication in Accidental and Programmed Cell Death: Apoptosis and Necrosis
Mitochondrial Involvement in Post-Tetanic Potentiation of Synaptic Transmission
Secondary Activation of a Cation Conductance Is Responsible for NMDA Toxicity in Acutely Isolated Hippocampal Neurons
Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity
Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine
The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal
...
1
2
3
...