Mitochondria: from cell death executioners to regulators of cell differentiation.

  title={Mitochondria: from cell death executioners to regulators of cell differentiation.},
  author={Atsuko Kasahara and Luca Scorrano},
  journal={Trends in cell biology},
  volume={24 12},
Most, if not all mitochondrial functions, including adenosine-5'-triphosphate (ATP) production and regulation of apoptosis and Ca(2+) homeostasis, are inextricably linked to mitochondrial morphology and dynamics, a process controlled by a family of GTP-dependent dynamin related 'mitochondria-shaping' proteins. Mitochondrial fusion and fission directly influence mitochondrial metabolism, apoptotic and necrotic cell death, autophagy, muscular atrophy and cell migration. In this review, we discuss… CONTINUE READING
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