Mitochondria: commanders of innate immunity and disease?

@article{Cloonan2012MitochondriaCO,
  title={Mitochondria: commanders of innate immunity and disease?},
  author={Suzanne M Cloonan and Augustine M. K. Choi},
  journal={Current opinion in immunology},
  year={2012},
  volume={24 1},
  pages={32-40}
}
Mitochondrial dysfunction is associated with the manifestation and origin of a plethora of diseases and disorders. Whilst classically the role of these archetypical 'powerhouses' in many disease phenotypes has been attributed to their ability to regulate cell metabolism and cell death pathways, emerging data posit that mitochondria may also act as powerful initiators and masters of the innate immune response. This new paradigm complements the current mitochondrial dogma, whereby molecules… CONTINUE READING
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