Mitochondria: More Than Just a Powerhouse

@article{McBride2006MitochondriaMT,
  title={Mitochondria: More Than Just a Powerhouse},
  author={Heidi M. McBride and Margaret Neuspiel and Sylwia Wasiak},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={R551-R560}
}

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References

SHOWING 1-10 OF 136 REFERENCES
Emerging functions of mammalian mitochondrial fusion and fission.
TLDR
Two inherited neuropathies, Charcot-Marie-Tooth type 2A and autosomal dominant optic atrophy, are caused by mutations in mitofusin 2 and OPA1, suggesting that proper regulation of mitochondrial dynamics is particularly vital to neurons.
Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes.
TLDR
Recent advances in the field of mitochondrial dynamics are reviewed and the importance of these pathways to human health is highlighted.
Topology of the Mitochondrial Inner Membrane: Dynamics and Bioenergetic Implications
TLDR
Computer modeling studies using the “Virtual Cell” program suggest that the shape of the inner membrane can influence mitochondrial function, and simulations indicate that narrow cristae junctions restrict diffusion between intracristal and external compartments, causing depletion of ADP and decreased ATP output inside the crists.
Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria
TLDR
Emphasis is laid on the methods for visualizing mitochondria in cells and following their behaviour, and Fluorescence methods provide unique possibilities because of their high resolving power and because some of the mitochondria‐specific fluorochromes can be used to reveal the membrane potential.
The ATP synthase is involved in generating mitochondrial cristae morphology
TLDR
A model is proposed of the assembly of ATP synthase dimers, taking into account the oligomerization of the yeast enzyme and earlier data on the ultrastructure of mitochondrial cristae, which suggests that the association of mitochondria of yeast cells deficient in either subunits e or g is involved in the control of the biogenesis of the inner mitochondrial membrane.
Mitochondrial fission in apoptosis, neurodegeneration and aging.
ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA
TLDR
It has been found that electron transport is required for the condensed-to-orthodox ultrastructural transformation which occurs in mitochondria under State IV conditions, i.e., under conditions in which exogenous substrate is present and ADP is deficient.
The machinery of mitochondrial inheritance and behavior.
TLDR
Characterization of the underlying molecular components of this machinery is providing insight into mechanisms regulating mitochondrial morphology and distribution.
...
...