Mitochondria: Dynamic Organelles in Disease, Aging, and Development

@article{Chan2006MitochondriaDO,
  title={Mitochondria: Dynamic Organelles in Disease, Aging, and Development},
  author={D. Chan},
  journal={Cell},
  year={2006},
  volume={125},
  pages={1241-1252}
}
  • D. Chan
  • Published 2006
  • Medicine, Biology
  • Cell
Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predictable set of defects in all tissues. However, mitochondrial dysfunction has pleiotropic effects in multicellular organisms. Clearly, much about the basic biology of mitochondria remains to be… Expand
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