Mitochondria, synaptic plasticity, and schizophrenia.

  title={Mitochondria, synaptic plasticity, and schizophrenia.},
  author={Dorit Ben-Shachar and Daphna Laifenfeld},
  journal={International review of neurobiology},
The conceptualization of schizophrenia as a disorder of connectivity, i.e., of neuronal?synaptic plasticity, suggests abnormal synaptic modeling and neuronal signaling, possibly as a consequence of flawed interactions with the environment, as at least a secondary mechanism underlying the pathophysiology of this disorder. Indeed, deficits in episodic memory and malfunction of hippocampal circuitry, as well as anomalies of axonal sprouting and synapse formation, are all suggestive of diminished… CONTINUE READING


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