Mitochondria, muscle health, and exercise with advancing age.

@article{Carter2015MitochondriaMH,
  title={Mitochondria, muscle health, and exercise with advancing age.},
  author={Heather N. Carter and Chris Chin Wah Chen and David A. Hood},
  journal={Physiology},
  year={2015},
  volume={30 3},
  pages={
          208-23
        }
}
Skeletal muscle health is dependent on the optimal function of its mitochondria. With advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part of this decline is due to reduced physical activity, whereas the remainder appears to be attributed to age-related alterations in mitochondrial synthesis and degradation. Exercise is an important strategy to stimulate mitochondrial adaptations in older individuals to foster improvements in muscle function and quality of… 

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References

SHOWING 1-10 OF 183 REFERENCES

Skeletal muscle aging and the mitochondrion

The interaction of aging and endurance exercise upon the mitochondrial function of skeletal muscle.

Age decreased the amount of intermyofibrillar mitochondrial protein, while training increased the mitochondrial protein of both regions of the cell, which resulted in a decrease in oxidative metabolism in the skeletal muscle.

Aberrant Mitochondrial Homeostasis in the Skeletal Muscle of Sedentary Older Adults

It is proposed that an active lifestyle is an important determinant of quality of life and molecular progression of aging in skeletal muscle of the elderly, and is a viable therapy for attenuating and/or reversing skeletal muscle strength declines and mitochondrial abnormalities associated with aging.

Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training.

The data suggest that an aerobic exercise program, even at an older age, can ameliorate the loss in skeletal muscle Mito content and may prevent aging muscle comorbidities; and the improvement of Mito function is all about content.

Effects of physical activity and age on mitochondrial function.

The results suggest that reduced physical activity is a major contribution to the decline in mitochondrial oxidations during ageing, and physical activity ameliorates and may even mask mitochondrial 'ageing' in muscle.

Elevated energy coupling and aerobic capacity improves exercise performance in endurance‐trained elderly subjects

Exercise performance of the elderly benefits from elevations in energy coupling and oxidative phosphorylation capacity at both the whole‐body and muscle levels that accompany endurance training.

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high‐ and low‐functioning elderly individuals

It is suggested that aging in skeletal muscle is associated with impaired mitochondrial function and altered biogenesis pathways and that this may contribute to muscle atrophy and the decline in muscle performance observed in the elderly population.

Skeletal muscle oxidative capacity in young and older women and men.

The data suggest that there is no requisite decline in skeletal muscle oxidative capacity with aging in humans, at least through the seventh decade, as supported by the stated hypothesis.
...