MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

@article{Kusminski2012MitoNEETdrivenAI,
  title={MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity},
  author={Christine M. Kusminski and William L Holland and Kai Sun and Jiyoung Park and Stephen B. Spurgin and Ying Lin and George R. Askew and Judith A. Simcox and Don A McClain and Cai Li and Phillip E Scherer},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={1539-1549}
}
We examined mouse models with altered adipocyte expression of mitoNEET, a protein residing in the mitochondrial outer membrane, to probe its impact on mitochondrial function and subsequent cellular responses. We found that overexpression of mitoNEET enhances lipid uptake and storage, leading to an expansion of the mass of adipose tissue. Despite the resulting massive obesity, benign aspects of adipose tissue expansion prevail, and insulin sensitivity is preserved. Mechanistically, we also found… CONTINUE READING

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