Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate

@inproceedings{Pathak2014MitoDCAAM,
  title={Mito-DCA: A Mitochondria Targeted Molecular Scaffold
for Efficacious Delivery of Metabolic Modulator Dichloroacetate},
  author={Rakesh Kumar Pathak and Sean Marrache and Donald A. Harn and Shanta Dhar},
  booktitle={ACS chemical biology},
  year={2014}
}
Tumor growth is fueled by the use of glycolysis, which normal cells use only in the scarcity of oxygen. Glycolysis makes tumor cells resistant to normal death processes. Targeting this unique tumor metabolism can provide an alternative strategy to selectively destroy the tumor, leaving normal tissue unharmed. The orphan drug dichloroacetate (DCA) is a mitochondrial kinase inhibitor that has the ability to show such characteristics. However, its molecular form shows poor uptake and… CONTINUE READING
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