Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time

@article{Ryu2006MitigationOR,
  title={Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time},
  author={Samuel Ryu and Andrew J J Kolozsvary and Kenneth A. Jenrow and Stephen L Brown and Jae Ho Kim},
  journal={Journal of Neuro-Oncology},
  year={2006},
  volume={82},
  pages={119-124}
}
Radiation-induced optic nerve damage was reduced by ramipril, a prodrug angiotensin-converting enzyme inhibitor (ACEI). This study was to determine the optimum dose and administration time of ramipril for mitigating radiation-induced optic neuropathy. Adult Fischer 344 male rats were treated with a single dose radiation 30 Gy by using radiosurgical technique. After irradiation, the animals were randomly assigned into groups of different ramipril doses and administration time; control (no… CONTINUE READING
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