Mitigation of oxygen-induced retinopathy in α2β1 integrin-deficient mice.

Abstract

PURPOSE The α2β1 integrin plays an important but complex role in angiogenesis and vasculopathies. Published GWAS studies established a correlation between genetic polymorphisms of the α2β1 integrin gene and incidence of diabetic retinopathy. Recent studies indicated that α2-null mice demonstrate superior vascularization in both the wound and diabetic… (More)
DOI: 10.1167/iovs.14-14061

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