Mitigation of nitrofurantoin-induced toxicity in the perfused rat lung.

@article{Bernard1997MitigationON,
  title={Mitigation of nitrofurantoin-induced toxicity in the perfused rat lung.},
  author={Claudine Bernard and Abdulmagid Alabdul Magid and T S Yen and B A Hoener},
  journal={Human & experimental toxicology},
  year={1997},
  volume={16 12},
  pages={727-32}
}
1. Nitrofurantoin is an antimicrobial agent which produces pulmonary toxicity via the redox cycling of the nitro group and its radical anion. This futile cycling triggers a complex series of events known collectively as oxidative stress. 2. In the isolated perfused rat lung, nitrofurantoin induced a decrease in tissue levels of glutathione but not protein… CONTINUE READING