Mitigation of caffeine-induced teratogenicity in mice by prior chronic caffeine ingestion.

@article{Terada1975MitigationOC,
  title={Mitigation of caffeine-induced teratogenicity in mice by prior chronic caffeine ingestion.},
  author={Mitsuyo Terada and H Nishmura},
  journal={Teratology},
  year={1975},
  volume={12 1},
  pages={
          79-87
        }
}
Pregnant A/J female mice, which had drunk tap water or a 0.05% caffeine solution for 8-19 weeks after weaning, were each injected sc with 150 or 250 mg/kg caffeine once on day 13 of gestation. After 150 mg/kg caffeine the frequencies at term of fetal death, external malformation, and subcutaneous hematomas were significantly lower in the caffeine- than water-drinking group. After 250 mg/kg caffeine the frequency of fetal death but not of malformations and hematomas was lower in the group with… CONTINUE READING