Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.

@article{Pabla2015MitigationOA,
  title={Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.},
  author={Navjotsingh Pabla and Alice A. Gibson and Mike Buege and Su Sien Ong and Lie Ting Li and Shuiying Hu and Guoqing Du and Jason A. Sprowl and Aksana Vasilyeva and Laura J. Janke and Eberhard Schlatter and Taosheng Chen and Giuliano Ciarimboli and Alex Sparreboom},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 16},
  pages={5231-6}
}
Acute kidney injury (AKI) is a potentially fatal syndrome characterized by a rapid decline in kidney function caused by ischemic or toxic injury to renal tubular cells. The widely used chemotherapy drug cisplatin accumulates preferentially in the renal tubular cells and is a frequent cause of drug-induced AKI. During the development of AKI the quiescent tubular cells reenter the cell cycle. Strategies that block cell-cycle progression ameliorate kidney injury, possibly by averting cell division… CONTINUE READING
11 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

A theoretical study of the structure and protonation of Palbociclib (PD 0332991)

  • I Alkorta, J Elguero
  • J Mol Struct 1056–1057(6):209–215
  • 2014

Similar Papers

Loading similar papers…