Mitigation of Methimazole-Induced Hepatic Injury by Taurine in Mice.

  title={Mitigation of Methimazole-Induced Hepatic Injury by Taurine in Mice.},
  author={Reza Heidari and Akram Jamshidzadeh and Nahid Keshavarz and Negar Azarpira},
  journal={Scientia pharmaceutica},
  volume={83 1},
Methimazole is the most widely prescribed antithyroid medication in humans. However, hepatotoxicity is a deleterious adverse effect associated with methimazole administration. No specific protective agent has been developed against this complication yet. This study was designed to investigate the role of taurine as a hepatoprotective agent against methimazole-induced liver injury in mice. Different reactive metabolites were proposed to be responsible for methimazole hepatotoxicity. Hence… CONTINUE READING
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