Mitigation of Ectopic Calcification in Osteopontin-Deficient Mice by Exogenous Osteopontin

@article{Ohri2004MitigationOE,
  title={Mitigation of Ectopic Calcification in Osteopontin-Deficient Mice by Exogenous Osteopontin},
  author={Rachit Ohri and Elyse L Tung and Rupak M. Rajachar and Cecilia M. Giachelli},
  journal={Calcified Tissue International},
  year={2004},
  volume={76},
  pages={307-315}
}
Ectopic calcification is a major cause of bioprosthetic heart valve failure. New therapeutic opportunities are offered by the growing understanding that ectopic calcification is an actively regulated process involving several key gene products. One of these products, osteopontin (OPN), is a glycosylated phosphoprotein previously shown to inhibit apatite crystal formation, induce carbonic anhydrase II, and promote mineral resorption. In this study, OPN-deficient mice (OPN−/−) were utilized as an… CONTINUE READING
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Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Role of carbonic anhydrase II in ectopic calcification.

  • Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • 2009
VIEW 6 EXCERPTS
CITES RESULTS, METHODS & BACKGROUND
HIGHLY INFLUENCED

Matricellular proteins in cardiac adaptation and disease.

  • Physiological reviews
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

Local Low-Dose Lovastatin Delivery Improves the Bone-Healing Defect Caused by Nf1 Loss of Function in Osteoblasts

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2010

The role of osteopontin in inflammatory processes

  • Journal of Cell Communication and Signaling
  • 2009
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2001
VIEW 1 EXCERPT

Osteopontin: a versatile regulator of inflammation and biomineralization.

  • Matrix biology : journal of the International Society for Matrix Biology
  • 2000
VIEW 1 EXCERPT

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