Mitigation of Ectopic Calcification in Osteopontin-Deficient Mice by Exogenous Osteopontin

@article{Ohri2004MitigationOE,
  title={Mitigation of Ectopic Calcification in Osteopontin-Deficient Mice by Exogenous Osteopontin},
  author={Rachit Ohri and Elyse L Tung and Rupak M. Rajachar and Cecilia M. Giachelli},
  journal={Calcified Tissue International},
  year={2004},
  volume={76},
  pages={307-315}
}
Ectopic calcification is a major cause of bioprosthetic heart valve failure. New therapeutic opportunities are offered by the growing understanding that ectopic calcification is an actively regulated process involving several key gene products. One of these products, osteopontin (OPN), is a glycosylated phosphoprotein previously shown to inhibit apatite crystal formation, induce carbonic anhydrase II, and promote mineral resorption. In this study, OPN-deficient mice (OPN−/−) were utilized as an… CONTINUE READING
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