Mithridates of Pontus and His Universal Antidote

  title={Mithridates of Pontus and His Universal Antidote},
  author={Adrienne Mayor},
  journal={Toxicology in Antiquity},
  • A. Mayor
  • Published 2019
  • History
  • Toxicology in Antiquity

Pharmacological stimulation of Wnt/beta-catenin signaling pathway attenuates the course of thioacetamide-induced acute liver failure.

Treatment with Wnt agonist attenuates the course of TAA-induced ALF in Lewis rats, both with treatment initiated immediately after hepatotoxic insult and in the phase when ALF has already developed, showing that the pharmacological stimulation of Wnt/beta-catenin signaling pathway can present a new approach to ALF treatment.

Scientific Knowledge and Technology, Animal Experimentation, and Pharmaceutical Development.

Human discovery of pharmacologically active substances is arguably the oldest of the biomedical sciences with origins >3500 years ago. Since ancient times, four major transformations have



Mithradates' Antidote – A Pharmacological Ghost

Two kinds of sources are available to the historian to reconstruct the first centuries of the history of Mithradates' antidote: biographical information on Mithradates' interests in medicine, and a

Poisons, poisoning and the drug trade in ancient Rome

The first recorded instance of poisoning in ancient Rome occurred in 331 BC when, during an epidemic, a large number of women were accused of concerted mass poisoning. Overreaction of the community

Bolatu's pharmacy theriac in early modern China.

The history of theriac illustrates the importance of the recipe for the naturalization of foreign objects in early modem Chinese medicine.

Attalus III of Pergamon : research toxicologist

Aboard the Beagle on its voyage into the South Atlantic in 1832, en route to tropical latitudes, the ever-observant Charles Darwin took advantage of an extended shore leave at Porto Praya on St Jago

Famous names in toxicology. Mithridates VI of Pontus, the first experimental toxicologist.

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Provincia Asia

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