Mithramycin selectively inhibits transcription of G-C containing DNA.

  title={Mithramycin selectively inhibits transcription of G-C containing DNA.},
  author={Donald M. Miller and D A Polansky and Shelia D. Thomas and Rabindranath Ray and Vaidehi Campbell and Juli{\'a}n S{\'a}nchez and Charles A. Koller},
  journal={The American journal of the medical sciences},
  volume={294 5},
Mithramycin induces a reversible inhibition of cellular RNA synthesis without affecting DNA synthesis. The authors have shown this drug induces myeloid differentiation of HL-60 promyelocytic leukemia cells and is an effective agent in certain patients with chronic granulocytic leukemia. In order to investigate the mechanism by which this drug inhibits RNA synthesis we have compared the effect of mithramycin on RNA synthesis by whole cells, isolated nuclei, and RNA synthesis by isolated E. coli… CONTINUE READING
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