Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells.

@article{Zhang2012MithramycinRB,
  title={Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells.},
  author={Mary F Zhang and Aarti Mathur and Yuwei Zhang and Sichuan Xi and Scott Michael Atay and Julie A. Hong and Nicole Datrice and Trevor Upham and Clinton D. Kemp and Robert T. Ripley and Gordon W. Wiegand and Itzak Avital and Patricia A. Fetsch and Haresh Mani and Daniel A Zlott and Robert Robey and Susan E Bates and Xinmin Li and M. Kalyana Kumar Rao and David S. Schrump},
  journal={Cancer research},
  year={2012},
  volume={72 16},
  pages={
          4178-92
        }
}
Cigarette smoking at diagnosis or during therapy correlates with poor outcome in patients with lung and esophageal cancers, yet the underlying mechanisms remain unknown. In this study, we observed that exposure of esophageal cancer cells to cigarette smoke condensate (CSC) led to upregulation of the xenobiotic pump ABCG2, which is expressed in cancer stem cells and confers treatment resistance in lung and esophageal carcinomas. Furthermore, CSC increased the side population of lung cancer cells… CONTINUE READING

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