Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression.

@article{Yang2010MithramycinIH,
  title={Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression.},
  author={Tzi-Peng Yang and H. Chiou and Ming-Chei Maa and C. Wang},
  journal={Chemico-biological interactions},
  year={2010},
  volume={183 1},
  pages={
          181-6
        }
}
  • Tzi-Peng Yang, H. Chiou, +1 author C. Wang
  • Published 2010
  • Chemistry, Medicine
  • Chemico-biological interactions
  • Mithramycin is an inhibitor of the binding of the Sp-family transcription factor to the GC box. Many studies show that mithramycin may reduce the expression of many oncogenes by inhibiting the mRNA and protein synthesis and it has been used as an antibiotic chemotherapy drug for a long time. Recently, Eps8 (EGFR pathway substrate 8) has been revealed to be a novel proto-oncogene related to cellular transformation, Rac activation and actin barbed-end-capping activity. Therefore, the aim of this… CONTINUE READING
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