Mithramycin impairs the release of 45Ca from bone induced by prostaglandin E2 or multiple myeloma sera. Implications for a novel means of local tumor control.

@article{Anderson1982MithramycinIT,
  title={Mithramycin impairs the release of 45Ca from bone induced by prostaglandin E2 or multiple myeloma sera. Implications for a novel means of local tumor control.},
  author={K. Anderson and M. Rubenstein and H. Sky-Peck},
  journal={Oncology},
  year={1982},
  volume={39 2},
  pages={
          72-77
        }
}
  • K. Anderson, M. Rubenstein, H. Sky-Peck
  • Published 1982
  • Medicine
  • Oncology
  • Some tumors release factors able to activate host osteoclasts. Mithramycin at sub-tumoricidal doses inhibits the release of calcium mediated by osteoclasts. If invasion of bone by a cancer requires activation of these cells, their intermittent "blockade' might impede the development of metastases to bone or their local extension. Fetal rat bones prelabelled with 45Ca were cultured in the presence of 10(-7) M prostaglandin E2, sera from normal individuals, or from patients with multiple myeloma… CONTINUE READING