Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells

@article{Bataller2008MithramycinSM,
  title={Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells},
  author={M. Bataller and C. M{\'e}ndez and J. Salas and J. Portugal},
  journal={Molecular Cancer Therapeutics},
  year={2008},
  volume={7},
  pages={2988 - 2997}
}
During a normal cell cycle, polyploidy and aneuploidy can be prevented by several checkpoints, which are mainly p53 dependent. Here, we show that treatment of HCT-116 (p53+/+) colon carcinoma cells with the novel antitumor antibiotic mithramycin SK (MSK) results in polyploidization and mitotic catastrophe, which occurs after a transient halt in G1 phase followed by the overtaking of the G2-M checkpoint when treated cells are incubated in a fresh drug-free medium. Cells reentering aberrant… Expand
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References

SHOWING 1-10 OF 52 REFERENCES
Transcriptional changes facilitate mitotic catastrophe in tumour cells that contain functional p53.
Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells.
Mitotic Catastrophe Results in Cell Death by Caspase-Dependentand Caspase-Independent Mechanisms
Apoptosis regulation in tetraploid cancer cells
p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.
  • I. Roninson, E. Broude, B. Chang
  • Biology, Medicine
  • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2001
...
1
2
3
4
5
...