Mithramycin: a very strong metal chelating agent.

@article{Demicheli1993MithramycinAV,
  title={Mithramycin: a very strong metal chelating agent.},
  author={C. Demicheli and A. Garnier-Suillerot},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1158 1},
  pages={
          59-64
        }
}
  • C. Demicheli, A. Garnier-Suillerot
  • Published 1993
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • The interaction of mithramycin (MTR) with Ca2+, Cd2+, Tb3+, Gd3+, Li+, Na+ and K+ ions has been studied by circular dichroism and absorption spectroscopy. Mithramycin binds strongly to Ca2+, Cd2+, Tb3+ and Gd3+ forming a 1:4 Ca2+: MTR entities with a left-handed screw conformation. The concentration of Ca2+ present in water currently used being about 10 microM, this leads to the conclusion that, in most of the experiments reported in the literature, about 40 microM mithramycin were actually… CONTINUE READING

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